Quinolone antimicrobial agents. 1. Versatile new synthesis of 1-alkyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
โ Scribed by Mitscher, L. A.; Gracey, H. E.; Clark, G. W.; Suzuki, T.
- Book ID
- 111910498
- Publisher
- American Chemical Society
- Year
- 1978
- Tongue
- English
- Weight
- 668 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
A series of substituted 1-cyclopropyl-6-fluoro-1, 4-dihydro-5-methyl-4-oxo-3-quinoline carboxylic acids was synthesized and tested for their in vitro and in vivo antibacterial activity. The introduction of a methyl group at the 5-position of quinoline nucleus enhanced characteristically the antibact
## Abstract The reaction of the alkylhydrazinoquinoxaline __N__โoxides **2aโd** with dimethyl acetylenedicarboxylate gave the dimethyl 1โalkylโ1,5โdihydropyridazino[3,4โ__b__]qumoxalineโ3,4โdicarboxylates **3aโd**, whose reaction with nitrous acid effected the C~4~โoxidation to afford the dimethyl