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Quinolinic acid modulates the activity of src family kinases in rat striatum: in vivo and in vitro studies

✍ Scribed by Alessio Metere; Cinzia Mallozzi; Maurizio Minetti; Maria Rosaria Domenici; Antonella Pèzzola; Patrizia Popoli; A. M. Michela Di Stasi

Book ID
111179517
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
261 KB
Volume
97
Category
Article
ISSN
0022-3042

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✍ Cinzia Mallozzi; Alberto Martire; Maria Rosaria Domenici; Alessio Metere; Patriz 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 265 KB

## Abstract Quinolinic acid (QA) is an endogenous excitotoxin acting on __N__‐methyl‐d‐aspartate receptors (NMDARs) that leads to the pathologic and neurochemical features similar to those observed in Huntington's disease (HD). The mechanism of QA toxicity also involves free radicals formation and