Quinolinic acid enhances permeability of rat brain microvessels to plasma albumin
✍ Scribed by František Št’astný; Ivana Škultétyová; Lioudmila Pliss; Daniela Ježová
- Book ID
- 117501478
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 332 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0361-9230
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## Abstract Permeability‐surface area products (PAs) of the blood‐nerve barrier (BNB) and blood‐brain barrier (BBB) to ^125^I‐labeled native bovine serum albumin (nBSA, pI ∼︁4), and to 2 cationized albumins (cBSA) of differing pI (pI ∼︁ 8 and 11), were quantitatively determined in awake rats, using
A gas chromatography/mass spectrometry assay is described to quantify the endogenous neurotoxin quinolinic acid (QUIN) in brain, whole blood, and plasma. High specificity and high sensitivity were obtained by using negative chemical ionization and accuracy was achieved by using ['80]QUlN as internal