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Quinine as a chiral additive in nonaqueous capillary zone electrophoresis

✍ Scribed by Apryll M. Stalcup; Kyung H. Gahm

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
448 KB
Volume
8
Category
Article
ISSN
1040-7685

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✦ Synopsis

Quinine was used as a chiral additive in nonaqueous capillary zone electrophoresis. The separation buffer consisted of ammonium acetate and quinine in methanol. Quinine was able to enantioresolve a number of N-3,5-dinitrobenzoylated amino acids as well as ( f. )-l,lr-binaphthyl-2,2'diyl hydrogen phosphate and N-[l-(1-naphthyl)ethyl]phthalamic acid. Enantioresolution deteriorated as the concentration of ammonium acetate was increased but improved with the addition of acetic acid. Chiral recognition seems to arise through an ion-pairing mechanism.

πŸ“œ SIMILAR VOLUMES

Enantiomeric separation of N-protected a
Enantiomeric separation of N-protected amino acids by non-aqueous capillary electrophoresis using quinine or Tert-butyl carbamoylated quinine as chiral additive
✍ Veronique Piette; Michael Lammerhofer; Wolfgang Lindner; Jacques Crommen πŸ“‚ Article πŸ“… 1999 πŸ› John Wiley and Sons 🌐 English βš– 137 KB πŸ‘ 2 views

A capillary electrophoretic (CE) method for the enantioseparation of N-protected chiral amino acids was developed using quinine and tert-butyl carbamoylated quinine as chiral selectors added to nonaqueous electrolyte solutions (NACE). A series of various N-derivatized amino acids were tested as chir