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Quinazoline Antifolates Thymidylate Synthase Inhibitors: Lipophilic Analogues with Modification to the C2-Methyl Substituent

✍ Scribed by Hennequin, Laurent F.; Boyle, F. Thomas; Wardleworth, J. Michael; Marsham, Peter R.; Kimbell, Rosemary; Jackman, Ann L.

Book ID: 118131377
Publisher: American Chemical Society
Year: 1996
Tongue: English
Weight: 441 KB
Volume: 39
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm950645n

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CB30865 (p-[N-(7-bromo-3,4-dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl+ ++)-N-(prop-2-ynyl)amino]-N-(3-pyridylmethyl)benzamide) is a quinazoline-based pyridine-containing compound that emerged from a programme aimed at the development of thymidylate synthase (TS) inhibitors as anticancer agents. Its