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Questioning the challenging role of epithelial-to-mesenchymal transition in liver injury

✍ Scribed by David Scholten; Ralf Weiskirchen

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
309 KB
Volume
53
Category
Article
ISSN
0270-9139

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✦ Synopsis

Hepatitis C virus (HCV) infection is closely tied to the lipid metabolism of liver cells. Here we identify the triglyceride-synthesizing enzyme diacylglycerol acyltransferase-1 (DGAT1) as a key host factor for HCV infection. DGAT1 interacts with the viral nucleocapsid core and is required for the trafficking of core to lipid droplets. Inhibition of DGAT1 activity or RNAi-mediated knockdown of DGAT1 severely impairs infectious virion production, implicating DGAT1 as a new target for antiviral therapy.

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