## Abstract ## Objective Monosodium urate monohydrate (MSU) crystals promote gouty inflammation that is critically mediated by neutrophil recruitment and activation. Interleukinโ8 (ILโ8) and closely related chemokines are major neutrophil chemotaxins in experimental gout. But MSU crystals also act
โฆ LIBER โฆ
Questionable role of leukotriene B4 in monosodium urate (MSU)-induced synovitis in the dog
โ Scribed by Richard P. Carlson; Joseph Chang; Louis J. Datko; Alan J. Lewis
- Book ID
- 119050260
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 314 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0090-6980
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## Abstract ## Objective The mechanism by which monosodium urate monohydrate (MSU) crystals intracellularly activate the cryopyrin inflammasome is unknown. The aim of this study was to use a mouse molecular geneticsโbased approach to test whether the leucineโrich repeat (LRR) domain of cryopyrin i