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Quercetin accelerates TNF-α-induced apoptosis of MC3T3-E1 osteoblastic cells through caspase-dependent and JNK-mediated pathways

✍ Scribed by Young-Ok Son; Sung-Ho Kook; Ki-Choon Choi; Yong-Suk Jang; Yong-Sung Choi; Young-Mi Jeon; Jong-Ghee Kim; Hyeon-Shik Hwang; Jeong-Chae Lee

Book ID: 113587221
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 726 KB
Volume: 579
Category: Article
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2007.10.003

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## Abstract Resistance to tumor necrosis factor (TNFα)‐induced apoptosis in various cancer cells has been attributed to the activation of the transcription factor NF‐κB. Ebselen (2‐phenyl‐1,2‐benzisoselenazol‐3[2H]one)—a selenoorganic compound is known to prevent TNFα‐mediated NF‐κB activity. As gl