Quasirandom distribution of α and β regions in globular proteins
✍ Scribed by Oleg B. Ptitsyn
- Book ID
- 112461052
- Publisher
- Springer
- Year
- 1983
- Tongue
- English
- Weight
- 442 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1573-4943
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Globular proteins fold into compact particles with interior amino acid residues shielded from the surrounding aqueous environment. An early hypothesis holds that entropic hydrophobic forces drive this phenomenon. However, previous analyses based on a binary description of the accessible surfaces of
An analysis of the amino acid distributions at 15 positions, viz., NЉ, NЈ, Ncap, N1, N2, N3, N4, Mid, C4, C3, C2, C1, Ccap, CЈ, and CЉ in 1,131 ␣-helices reveals that each position has its own unique characteristics. In general, natural helix sequences optimize by identifying the residues to be avoi