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Quasielastic light-scattering studies on human fibrinogen and fibrin. II. Fibrin polymerization

✍ Scribed by G. R. Palmer; O. G. Fritz

Publisher
Wiley (John Wiley & Sons)
Year
1979
Tongue
English
Weight
683 KB
Volume
18
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The shape of fibrin intermediate polymers as well as the rate of fibrinogen polymerization was studied using diffusion measured by quasielastic light scattering. After their length distribution was narrowed by gel filtration, the polymers yielded translational and rotational diffusion coefficients of 0.37 ± 0.05 × 10^−7^ cm^2^ sec^−1^ and 142 ± 32 sec^−1^, respectively. Theoretical considerations indicated the polymers to be rigid rods. The rate of polymerization of fibrinogen monitored by diffusion paralleled that provided by simulataneous intensity measurements. Both monitors indicated polymerization occurs most rapidly at 30°C.

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