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Quasielastic light scattering investigation of the isothermal “helix to extended-coil” transition of poly-L-lysine HBr

✍ Scribed by A. M. Jamieson; L. Mack; A. G. Walton

Publisher
Wiley (John Wiley & Sons)
Year
1972
Tongue
English
Weight
700 KB
Volume
11
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

The quasielastic light scattering of poly‐L‐lysine HBr in aqueous solutions has been examined over a variety of pH values where the polymer is in different conformations. Analysis of the spectra demonstrates that as the pH is lowered, the polymer changes from an extended anisotropic from through a collapsed randomized state to a larger isotropic form. These data support the current view that the polymer undergoes a conformational change from an α‐helical form to a “kinked” extended‐coil conformation through an intermediate partially α‐helical state in which internal packing of the helical portions occurs. Finally, a value for the rate of propagation of the unwinding of the α‐helix has been obtained.

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Spin-label studies of the pH-induced ran
Spin-label studies of the pH-induced random coil to α-helix conformational transition in poly(L-lysine)
✍ James F. Skinner; Hugh H. Calkins; W. Conrad Liles Jr.; Lawrence J. Kaplan 📂 Article 📅 1982 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 756 KB

## Abstract Poly(L‐lysine) of various molecular weights between 2700 and 475,000 was spin‐labeled. From the electron spin resonance spectra, the degree of freedom of the nitroxide was determined by calculation of the rotational correlation time as the poly(L‐lysine) underwent the pH‐induced random