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Quartz Crystal Microbalance Study of DNA Immobilization and Hybridization for Nucleic Acid Sensor Development

✍ Scribed by Caruso, Frank; Rodda, Elke; Furlong, D. Neil; Niikura, Kenichi; Okahata, Yoshio


Book ID
111678414
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
186 KB
Volume
69
Category
Article
ISSN
0003-2700

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A 20-mer DNA probe complementary to a part of an oncogene v-myc, having a mercaptohexyl group at the 5'-end, was immobilized on a gold electrode of a quartz crystal microbalance (QCM). The quantity of the probe immobilized on the electrode depended on the pH. Under acidic or basic immobilization con