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Quantition of biliary F2-isoprostane excretion as a measure of hepatic lipid peroxidation in vivo

✍ Scribed by J.A. Awad; R.F. Burk; L.J. Roberts II


Book ID
113386021
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
158 KB
Volume
15
Category
Article
ISSN
0891-5849

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Excretion of F2-isoprostanes in bile: A
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Lipid peroxidation is believed to be an important mechanism of liver injury caused by some xenobiotics. However, it has been difficult to demonstrate and quantify this process in uiuo. Moreover, little is known about the disposition of lipids oxidized in the liver. Fz-isoprostanes are prostanoids pr

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This study aimed at comparing the two most commonly utilized methods for measuring urinary F 2 -isoprostanes, currently considered one of the best available markers of in vivo lipid peroxidation. The F 2isoprostanes were measured in 24-h urine samples from 14 male subjects using electron capture neg