Quantitative tissue sodium concentration mapping of the growth of focal cerebral tumors with sodium magnetic resonance imaging
✍ Scribed by Keith R. Thulborn; Denise Davis; Holly Adams; Tatyana Gindin; Joe Zhou
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 233 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0740-3194
No coin nor oath required. For personal study only.
✦ Synopsis
Tissue sodium concentration (TSC), as determined by in vivo 23 Na magnetic resonance imaging (MRI) and the ex vivo classical 22 Na radionuclide dilution assay (RDA), has been compared in a rat model of a focal glioma. The 23 Na MRI method used a three-dimensional, twisted projection acquisition scheme at short echo time to minimize signal losses from relaxation of transverse magnetization. Calibration standards within the field of view allowed quantification of the sodium signal in terms of a TSC after correction for B 1 nonuniformity and tissue water concentration. The 23 Na MRI method measured focally increased TSC values in tumors that were equivalent statistically to the destructive 22 Na RDA method. The noninvasive 23 Na MRI method provided a quantitative means with which to monitor focal brain tumor growth.