Quantitative Structure−Metabolism Relationships: Steric and Nonsteric Effects in the Enzymatic Hydrolysis of Noncongener Carboxylic Esters

Importance of steric effect and evaluati

Importance of steric effect and evaluation of quantitative structure reactivity relationship (QSRR) in the quaternization reaction of benzothiazoles and phenacyl bromide

✍ Bijay Kumar Mishra; Arabinda Sharma; Gopabandhu Behera 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 313 KB

The kinetics of reaction of substituted 2-aminobenzothiazoles and phenacyl bromide have been followed conductometrically and in some cases, argentometrically. Both the methods produced almost the same rate constants. Substituents at position 5 of the benzothiazole nucleus behave like para substituen