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Quantitative structure–activity relationship studies of vitamin D receptor affinity for analogues of 1α,25-dihydroxyvitamin D3. 1: WHIM descriptors

✍ Scribed by Maykel Pérez González; Pedro Lois Suárez; Yagamare Fall; Generosa Gómez


Book ID
108073784
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
116 KB
Volume
15
Category
Article
ISSN
0960-894X

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1␣,25-dihydroxyvitamin D 3 (1␣,25(OH) 2 D 3 ), the active metabolite of vitamin D, mediates many of its effects through the intranuclear vitamin D receptor (VDR, NR1I1), that belongs to the large superfamily of nuclear receptors. Vitamin D receptor can directly regulate gene expression by binding to