Quantitative structure-activity relationships of phenyl N-methylcarbamates against the smaller brown planthopper and its acetylcholinesterase

Probing the peripheral anionic site of a

Probing the peripheral anionic site of acetylcholinesterase with quantitative structure activity relationships for inhibition by biphenyl-4-acyoxylate-4′-N-Butylcarbamates

✍ Gialih Lin; Gan-Hong Chen; Shih-Chieh Yeh; Chun-Ping Lu 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 294 KB 👁 1 views

## Abstract Biphenyl‐4‐acyoxylate‐4′‐__N__‐butylcarbamates 1–8 are synthesized from 4,4′‐biphenol and are characterized as the pseudosubstrate inhibitors of acetylcholinesterase. In other words, the inhibitors bind to the enzyme and react with the enzyme to form the tetrahedral intermediates for th