Quantitative Prediction of Human Intestinal Glucuronidation Effects on Intestinal Availability of UDP-Glucuronosyltransferase Substrates Using In Vitro Data
β Scribed by Nakamori, F.; Naritomi, Y.; Hosoya, K.-i.; Moriguchi, H.; Tetsuka, K.; Furukawa, T.; Kadono, K.; Yamano, K.; Terashita, S.; Teramura, T.
- Book ID
- 118144255
- Publisher
- American Society for Pharmacology and Experimental Therapeutics
- Year
- 2012
- Tongue
- English
- Weight
- 357 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0090-9556
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Although hepatic availability has been extensively studied to assess the oral bioavailability of drugs, intestinal availability has not, especially that related to conjugative metabolism (phase II metabolism). The present study assessed intestinal presystemic availability by integrating the reported
The inhibitory potencies of non-steroidal anti-inflammatory drugs (NSAIDs) on UDP-glucuronosyltransferase (UGT) 1A9 activity were investigated in recombinant human UGT1A9 using 4-methylumbelliferone (4-MU) as a substrate for glucuronidation. 4-MU glucuronidation (4-MUG) showed Michaelis-Menten kinet