✦ LIBER ✦

Quantitative nuclear magnetic resonance analysis of solid formoterol fumarate and its dihydrate

✍ Scribed by David C. Apperley; Robin K. Harris; Tomas Larsson; Torsten Malmstrom

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 134 KB
Volume: 92
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.10500

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✦ Synopsis

Carbon-13 cross-polarization magic-angle spinning nuclear magnetic resonance spectra of anhydrous formoterol fumarate and the dihydrate are presented, together with some relaxation time measurements. The latter enabled quantitation of mixtures of the anhydrate and dihydrate to be made. Quantitative nuclear magnetic resonance measurements were then performed on mixtures of the two forms formulated in lactose. Relative amounts of the forms could be assessed at a total formulation level of 2%, whereas the dihydrate on its own in lactose was detectable at the 0.45% level. The optimum experiment involves dipolar dephasing, because that minimizes the intensity of signals from the lactose.

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