β Scribed by Victor M. Haughton; F. Zerrin Yetkin; Stephen M. Rao; Alfred A. Rimm; Mary E. Fischer; R. Anne Papke; Robert K. Breger; Bhupendra O. Khatri
No coin nor oath required. For personal study only.
In patients with multiple sclerosis (MS), the apparently uninvolved cerebral white matter between demyelinated plaques may have biochemical abnormalities. To what degree the changes in the white matter contribute to symptomatology in MS is unknown. In 39 patients with multiple sclerosis, and in 39 ageβmatched nondiseased volunteers, T1 and T2 were calculated from spinβecho images in four regions of apparently uninvolved white matter. In three of four white matter areas, the average T1 and T2 were significantly longer in the patients than in the controls. The T1 correlated with the disability, measured by the Kurtzke Extended Disability Status Scale, although the correlation was marginally significant. The results suggest that in patients with MS, white matter disease that is not visualized in MR as distinct foci of abnormal signal intensity may contribute to disease burden and disability.
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## Abstract ## Purpose To investigate whether a recently improved version of the threeβdimensional double inversionβrecovery (3DβDIR) technique enables the in vivo detection of hippocampal lesions in multiple sclerosis (MS). ## Materials and Methods Magnetic resonance images of 16 patients and n
Magnetic resonance imaging (MRI) has been shown in a number of studies to be a very sensitive method for detecting focal areas of damage in the white matter of the cerebral hemispheres. This sensitivity has been reflected in the wave of enthusiasm with which MRI has been used in the diagnostic evalu