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Quantitative Modeling of Passive Permeation through the Blood Brain Barrier

โœ Scribed by Filipe, Hugo; Salvador, Armindo; Vaz, Winchil; Moreno, Maria Joao


Book ID
119205249
Publisher
Biophysical Society
Year
2009
Tongue
English
Weight
64 KB
Volume
96
Category
Article
ISSN
0006-3495

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The blood-brain barrier permeation has been investigated by using a topological substructural molecular design approach (TOPS-MODE). A linear regression model was developed to predict the in vivo blood-brain partitioning coefficient on a data set of 119 compounds, treated as the logarithm of the blo