This study was based on 358 cases with abnormal smears referred for colposcopy and HPV DNA testing. We analysed: 1) the frequency of different grades of cyto-and histopathologic findings; 2) the frequency and relative amount of HPV DNA with the hybrid capture assay (HCA) in swabs, and the frequency
✦ LIBER ✦
Quantitative methylation-specific PCR for the detection of aberrant DNA methylation in liquid-based Pap tests
✍ Scribed by Kahn, Steven L. ;Ronnett, Brigitte M. ;Gravitt, Patti E. ;Gustafson, Karen S.
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 116 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0008-543X
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Many human syndromes involve a loss of imprinting (LOI) due to a loss (LOM) or a gain of DNA methylation (GOM). Most LOI occur as mosaics and can therefore be difficult to detect with conventional methods. The human imprinted 11p15 region is crucial for the control of fetal growth, and LOI at this l