Quantitative measurement of telomerase reverse transcriptase (hTERT) mRNA in urothelial cell carcinomas
β Scribed by Jacques B. De Kok; Jack A. Schalken; Tilly W. Aalders; Theo J.M. Ruers; Hans L. Willems; Dorine W. Swinkels
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- French
- Weight
- 52 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0020-7136
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π SIMILAR VOLUMES
Telomerase activity is suppressed in normal human somatic tissues but is activated in cancer cells and immortal cell lines. The reverse transcriptase (RT) subunit human telomerase reverse transcriptase (hTERT) is the key regulator of telomerase activity. The hTERT promoter contains E-box elements an
## Abstract ## BACKGROUND The objectives of this study were to evaluate the diagnostic and prognostic relevance of human telomerase reverse transcriptase (hTERT) detected in situ in patients with nonsmall cell lung carcinoma (NSCLC) and to investigate the possible correlations between hTERT mRNA i