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Quantitative Measurement of Superoxide Generation Using the Spin Trap 5-(Diethoxyphosphoryl)-5-methyl- 1-pyrroline-N-oxide

✍ Scribed by Valerie Roubaud; Sornampillai Sankarapandi; Periannan Kuppusamy; Paul Tordo; Jay L. Zweier

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 181 KB
Volume: 247
Category: Article
ISSN: 0003-2697
DOI: 10.1006/abio.1997.2067

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The ability of ten cyclic nitrones, 5-alkyl-5-methyl-1-pyrroline N-oxides, to trap a variety of short-lived free radicals has been investigated using ESR spectroscopy. Stereospecific spin trapping by these nitrones has been demonstrated by comparison of the ESR spectra of their adducts with the ESR