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Quantitative liquid chromatography, thermospray/tandem mass spectrometry (LC/TSP/MS/MS) analysis of some thermolabile benzodiazepines in whole-blood

✍ Scribed by Anthonie M.A. Verweij; Peter J.L. Lipman; Peter G.M. Zweipfenning

Publisher: Elsevier Science
Year: 1992
Tongue: English
Weight: 475 KB
Volume: 54
Category: Article
ISSN: 0379-0738
DOI: 10.1016/0379-0738(92)90081-7

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✦ Synopsis

An LC/TSP/MS/MS selected reaction monitoring (SRM) method in the daughter ion scan mode can be applied successfully for the quantitative determination of thermolabile benzodiazepines in whole-blood following an Extrelut extraction method. Detection limits as low as 100 pg per injection can be reached for all benzodiazepines. The benzodiazepines under investigation proved to be stable, with the exception of ketazolam for which complete degradation to diazepam was observed.

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