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Quantitative importance of biliary excretion to the turnover of hepatic lysosomal enzymes

โœ Scribed by Akira Nakano; David L. Marks; Pamela S. Tietz; Piet C. De Groen; Nicholas F. Larusso


Book ID
119155963
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
620 KB
Volume
22
Category
Article
ISSN
0270-9139

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The turnover rate of an individual protein is a function of the rates of synthesis and loss of that protein. For most intracellular proteins, loss occurs through digestion by lysosomal or cytosolic proteases. Although a significant proportion of hepatic lysosomal enzymes is released from the hepatoc

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In these experiments, we tested two hypotheses: first, that Triton WR-1339, a nonionic detergent which is sequestered in hepatocyte lysosomes, undergoes biliary excretion; and second, that Triton WR-1339, which also alters serum lipid levels and modifies hepatic catabolism of lipoproteins, affects t