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Quantitative histopathology and chromosome 9 polysomy in a clinical trial of 4-HPR

✍ Scribed by Jose-Miguel Yamal; Dennis Cox; Walter N Hittelman; Iouri Boiko; Anais Malpica; Martial Guillaud; Calum MacAulay; Michele Follen; Anne-Therese Vlastos


Book ID
113959331
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
970 KB
Volume
94
Category
Article
ISSN
0090-8258

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The pharmacokinetics of CI-921 were studied after 65 infusions over a 20-fold dose range (13-270 mg/m2 per day) in 16 patients during a phase 1 trial. CI-921 was given by a 15 min infusion on three consecutive days. Plasma samples were collected after the first and third infusions, and urine, at 6 h