Quantitative evaluation of individual variability in the heat-resistances of cells and their contractile models
✍ Scribed by Ushakov, B. ;Amosova, I. ;Pashkova, I. ;Chernokozheva, I.
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 893 KB
- Volume
- 167
- Category
- Article
- ISSN
- 0022-104X
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✦ Synopsis
- Evaluation of thermostability by the time required to inactivate cells and models at a constant temperature reveals significant differences between specimens from the same population.
( 2 ) The analysis of statistical distribution of the thermostabilities of cells and cellular models shows that it is advantageous to treat the logarithms of the inactivation times rather than the numerical values themselves. (a) The distribution curve in this case is symmetric while that of the numerical values for some of the objects studied is an asymmetric one, and (b) the value of variance of logarithm distribution does not depend on the temperature at which the heart-resistance is measured.
(3) Standard deviation or distribution variance of logarithms of inactivation times of cells and models may be used as quantitative criteria of intrapopulational variability in heat-resistance. When comparing variablities in the heat-resistance of nonhomologous cells and models, special attention should be paid to the possible effect of methodological factors on the total magnitude of the variance or standard error.
(4) Frequency curves of the thermostabilities of cells and models exhibit only a single maximum and have a continuous character which may indicate polygenic inheritance of heat-resistance.