Quantitative determination of α- and γ-2,4-dinitrophenyl-isomers of α,γ-diaminobutyric acid with an automatic amino acid analyzer as a method of studying Nα ⇄ Nγ migration in peptides of α,γ-diaminobutyric acid and polymyxin M
✍ Scribed by A.B. Silaev; L.A. Baratova; G.S. Katrukha
- Publisher
- Elsevier Science
- Year
- 1966
- Tongue
- English
- Weight
- 637 KB
- Volume
- 24
- Category
- Article
- ISSN
- 1873-3778
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✦ Synopsis
According to the data reported in the literature, salts of antibiotics of the polymyxin group are stable in weak acid and neutral solutions, but are inactivated in acid solutions and in particular in alkaline ones l--b. The study of the alkaline inactivation of the antibiotic polymyxin M has shown that in 0.1 N NH,,OH at 37" the antibiotic almost completely loses its antibacterial activity in three to five days097. The inactivation is causecl by the change of the secondary structure of the molecule;by a partial rnremi7lfinn nC 1-11~ zaminn ?riiIc fnrminc fhP rn~l~rlll~ t-d nnlvmvwin M ap_cl, fi_~_~~~y by _.." ___I__ &Cur*_,--__ "I__ b"l*