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Quantitative determination of saquinavir from Caco-2 cell monolayers by HPLC-UV

โœ Scribed by Sibel Demirbas Ucpinar; Salomon Stavchansky


Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
78 KB
Volume
17
Category
Article
ISSN
0269-3879

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Determination ofin vitro permeability of
โœ Wang, Zhen; Hop, Cornelis E. C. A.; Leung, Kwan H.; Pang, JianMei ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 74 KB ๐Ÿ‘ 1 views

Studying the permeability of compounds across a Caco-2 cell monolayer is an established in vitro model to screen for oral absorption and to evaluate the mechanism of transport. This assay can also be used to evaluate compounds as potential P-glycoprotein substrates and/or inhibitors. The traditional