Quantitative determination of absorption and elimination of carbon disulfide through different channels in human body
✍ Scribed by Harashima, Susumu ;Masuda, Yoshinori
- Publisher
- Springer-Verlag
- Year
- 1962
- Weight
- 387 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0367-9977
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✦ Synopsis
There are several valuable reports on carbon disulfide (CS2) elimination through the expired air and urine of human subjects that inhaled the gas.
These were presented by MeK~E et al. (1943), and T~IsI~G~ and SoucnK (1949) in other countries, and by KO~AYAS~I (1952) and SuzuKI et al. (1957) in Japan. According to animal experiments by McKEE et al. (1943), ST~ITTMATT~R et al. (1950), TOYA~A et al. (1953), and Kvs.(~o (1954), the chief route of elimination of CSe in a gaseous state is the expired air, and some portion of the absorbed gas is metabolized in the body, and the metabolites are excreted in the urine, as verified by McKEE et al. (1943), GoTo et al. (1959) and MASUDA (1960).
There are, however, no exact quantitative measurements of CS 2 eliminated as gas out of the amount absorbed during the human exposure. The authors supposed that CS2 absorbed may be eliminated through the skin besides the expired air and urine. Calculating the amount of CS 2 retained in the body by measuring CS2 in the inspiring and exspiring airs during the expcrimentM exposure, they succeeded in making a balance sheet for CS~ in a gaseous state in the body which eliminated the gas in the expired air, the skin and the urine. Since CS2 elimination in the feces was proved to be non-existent by McK~E et M. (1943), it was not touched upon in the present experiment.