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Quantitative characterization of the nucleophile reactivity in penicillin acylase-catalyzed acyl transfer reactions

✍ Scribed by Maxim I Youshko; Ghermes G Chilov; Tatyana A Shcherbakova; Vytas K Švedas


Book ID
108497810
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
169 KB
Volume
1599
Category
Article
ISSN
1570-9639

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## Abstract The acyl transfer reaction of __S__‐glutathionyl benzoate (GSB) is catalyzed by a rationally designed mutant of human glutathione transferase A1‐1, A216H. The catalyzed reaction proceeds via the formation of an acyl intermediate and has been studied in the presence of nitrogen, oxygen,