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Quantitative aspects of T-cell recognition: from within the antigen-presenting cell to within the T cell

✍ Scribed by Pierre Bongrand; Bernard Malissen

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
275 KB
Volume
20
Category
Article
ISSN
0265-9247

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✦ Synopsis

T lymphocytes circulate continually throughout the peripheral lymphoid organs, where they scrutinize the surface of cells to detect the presence of nonself protein fragments. During the last years, many facets of T-cell function have been unravelled. After being bound by major histocompatibility complex (MHC) molecules, peptides derived from nonself as well as from self proteins are delivered to the cell surface. A few copies of a nonself peptide ''presented'' at the cell surface in the context of an MHC molecule can be detected by specific T cells, and suffice to trigger T-cell activation. This paper reviews the requirements imposed on T cells to fulfill this exquisite sensitivity.

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