Quantitative and qualitative analysis of tonsillar IgA in IgA nephropathy patients
β Scribed by Akihiko ITOH; Hitoo IWASE; Toru TAKATANI; Ikuko NAKAMURA; Yoshiyuki HIKI; Makito OKAMOTO
- Book ID
- 108958721
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 112 KB
- Volume
- 8
- Category
- Article
- ISSN
- 1320-5358
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## Abstract Diagnostic analysis of clinical markers including serum IgA levels and serum IgA/C3 ratio in patients with IgA nephropathy is described. One hundred patients with IgA nephropathy (IgA nephropathy group) and 100 patients with other primary glomerular diseases (nonβIgA nephropathy group)
The mechanism of mesangial IgA deposition is poorly understood in IgA nephropathy (IgAN). Abnormal glycosylation of carbohydrate moieties in the hinge region of the IgA molecule has recently attracted much attention. In this report, we studied galactosylation and sialylation profiles in ΞΊand Ξ»-IgA 1
IgA nephropathy (IgAN) is the most common form of chronic glomerulonephritis. Although glomerular deposition of complement components is well known, the evidence of serological complement activation in IgAN is inconclusive. We hypothesized that serum levels of complement components and regulatory pr