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Quantitative analysis of the distribution of99mTc-labelled ethylene hydroxy diphosphonate in young rats

✍ Scribed by Madeleine Rohlin; Bertil Nosslin

Publisher: Springer
Year: 1977
Tongue: English
Weight: 255 KB
Volume: 2
Category: Article
ISSN: 0340-6997
DOI: 10.1007/bf00253683

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✦ Synopsis

The distribution of 99mTc-labelled ethylene 1-hydroxy-1,1-diphosphonate (EHDP) in young rats was studied 1, 3, 6 and 9 h after intraperitoneal injection. The concentration of 99mTc in bone was 8-10 times higher than that in the kidneys and 20-1000 times higher than those in other soft tissues. The concentration in bone remained constant throughout the observation time. In some of the animals sacrificed after 3, 6, or 9 h the uptake in the liver and spleen was higher than that found in the majority of the animals.

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