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Quantitative analysis of phosphorothioate oligonucleotides in biological fluids using fast anion-exchange chromatography

โœ Scribed by A.J. Bourque; A.S. Cohen

Publisher
Elsevier Science
Year
1993
Weight
594 KB
Volume
617
Category
Article
ISSN
0378-4347

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Based on a novel method for solid-phase extraction using cationic polystyrene nanoparticles, the suitability of the extraction procedure for quantitation of terminally and backbone-modified antisense oligonucleotides was investigated. Extractions were carried out from both human plasma and urine. Qu