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Quantitative analysis of lentiviral transgene expression in mice over seven generations

✍ Scribed by Yong Wang; Yong-tao Song; Qin Liu; Cang’e Liu; Lu-lu Wang; Yu Liu; Xiao-yang Zhou; Jun Wu; Hong Wei

Publisher
Springer Netherlands
Year
2010
Tongue
English
Weight
547 KB
Volume
19
Category
Article
ISSN
0962-8819

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## Abstract Summary: Despite the overall successful application of the tet‐system to regulate gene expression in vitro and in vivo, nothing is known so far about the long‐term stability of this system in transgenic mice. In this study, mice of generation F2, F3, F4, or F10 of two independent tTA^CM