Many nongenotoxic hepatocarcinogens can induce cell proliferation, and inhibit apoptosis and gap-junctional-intercellular communication (GJIC). GJIC, the movement of small molecules (less than 1.2 kD) through membrane channels, is important in regulating cellular homeostasis and differentiation. The
Quantitative analysis of gap-junctional intercellular communication in precision-cut mouse liver slices
โ Scribed by Alessandro Romualdi; Heiner Niessen; Frank Dombrowski; Klaus Willecke; Thomas Ott
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 135 KB
- Volume
- 307
- Category
- Article
- ISSN
- 0302-766X
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## Abstract Gap junctional intercellular communication (GJIC) maintains normal growth and differentiation of cells in a tissue. The intercellular molecules traversing gap junctions are largely unknown, but the molecular weight (MW) cutoff is normally 1200 Da. No differences in dye transfer were obs
We found that a rat liver epithelial cell line (IAR 20) expresses connexin 43, the major cardiac gap-junction protein, but not connexin 26 or connexin 32, major liver gap-junction proteins. The effects of TPA on connexin 43 expression in IAR 20 were investigated using northern blot analysis, western