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Quantitative analysis of EGR proteins binding to DNA: assessing additivity in both the binding site and the protein

✍ Scribed by Jiajian Liu; Gary D Stormo


Book ID
114999945
Publisher
BioMed Central
Year
2005
Tongue
English
Weight
383 KB
Volume
6
Category
Article
ISSN
1471-2105

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The loading of Ku onto a DNA end in a double-strand DNA break is thought to be one of the "rst steps in the non-homologous DNA end joining (NHEJ) pathway, giving it an essential role in the maintenance of genomic integrity. The binding of Ku to DNA is complicated since DNA can accommodate multiple K