✦ LIBER ✦

Quantitative Analysis of Dynamic Gd-DTPA Enhancement in Breast Tumors Using a Permeability Model

✍ Scribed by Paul S. Tofts; Bruce Berkowitz; Mitchell D. Schnall

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 488 KB
Volume: 33
Category: Article
ISSN: 0740-3194
DOI: 10.1002/mrm.1910330416

No coin nor oath required. For personal study only.

✦ Synopsis

The MRI signal enhancement in a breast tumor, measured as a function of time after a bolus injection of Gd-DTPA, may contain enough information to difterentiate malignant from benign tissue. We find a physiological model for measuring capillary permeability and leakage space (P. S. Tofts, A. G. Kermode, measurement of the blood-brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn. Reson. Med. 17, 357-367 (1991)) fits the data well. The enhancement curve is particularly sensitive to the preinjection T, of the tumor, the dose, and the time of injection. This model may provide a means of characterizing the pathophysiology of breast tumors from the Gd-DTPA enhancement curve.

📜 SIMILAR VOLUMES

Assessment of tumor oxygenation in human

Assessment of tumor oxygenation in human cervical carcinoma by use of dynamic Gd-DTPA-enhanced MR imaging

✍ Heidi Lyng; Ann O. Vorren; Kolbein Sundfør; Ingeborg Taksdal; Hans H. Lien; Olav 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 207 KB

## Abstract Increased knowledge of the physiological basis behind the signal enhancement in tumors during dynamic contrast‐enhanced magnetic resonance (MR) imaging may be useful in development of predictive assays based on this technique. In the present work, the relative signal intensity (RSI) inc

Assessment of tumor angiogenesis: dynami

Assessment of tumor angiogenesis: dynamic contrast-enhanced MRI with paramagnetic nanoparticles compared with Gd-DTPA in a rabbit Vx-2 tumor model

✍ Andrea Kassner; Rebecca E. Thornhill; Fang Liu; Patrick M. Winter; Shelton D. Ca 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB

## Abstract The purpose of this study was to evaluate the suitability of a macromolecular MRI contrast agent (paramagnetic nanoparticles, PNs) for the characterization of tumor angiogenesis. Our aim was to estimate the permeability of PNs in developing tumor vasculature and compare it with that of

Dynamic contrast-enhanced MRI using Gd-D

Dynamic contrast-enhanced MRI using Gd-DTPA: Interindividual variability of the arterial input function and consequences for the assessment of kinetics in tumors

✍ Ruediger E. Port; Michael V. Knopp; Gunnar Brix 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 244 KB 👁 1 views

Gd-DTPA kinetics in arterial blood was investigated by dynamic MRI in 47 patients with malignant and benign mammary tumors. Signal enhancement was monitored for 10 min after the beginning of a 1-min infusion of 0.1 mmol/kg Gd-DTPA. Kinetics in blood was biexponential with median half-lives of 21 sec

MRI methods for evaluating the effects o

MRI methods for evaluating the effects of tyrosine kinase inhibitor administration used to enhance chemotherapy efficiency in a breast tumor xenograft model

✍ S.O. Aliu; L.J. Wilmes; M.M. Moasser; B.C. Hann; K.-L. Li; D. Wang; N.M. Hylton 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 472 KB 👁 2 views

## Abstract ## Purpose To evaluate whether quantitative MRI parameters are sensitive to the effects of the tyrosine kinase inhibitor gefitinib and can discriminate between two different treatment protocols. ## Materials and Methods Untreated mice with BT474 breast tumor xenografts were character

Assessment of tumor blood flow in breast

Assessment of tumor blood flow in breast tumors with T1-dynamic contrast-enhanced MR Imaging: Impact of dose reduction and the use of a prebolus technique on diagnostic efficacy

✍ Smitha Makkat; Robert Luypaert; Steven Sourbron; Tadeusz Stadnik; Johan De Mey 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 275 KB 👁 1 views

## Abstract ## Purpose: To prospectively evaluate whether dose reduction and the application of a prebolus technique can effectively alleviate signal saturation effects in T1 dynamic contrast enhanced (T1‐DCE) magnetic resonance imaging (MRI) data in breast tumors and lead to increased diagnostic