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Quantitative analysis of dopamine transporters in human brain using [11C]PE2I and positron emission tomography: evaluation of reference tissue models

โœ Scribed by Chie Seki; Hiroshi Ito; Tetsuya Ichimiya; Ryosuke Arakawa; Yoko Ikoma; Miho Shidahara; Jun Maeda; Akihiro Takano; Hidehiko Takahashi; Yuichi Kimura; Kazutoshi Suzuki; Iwao Kanno; Tetsuya Suhara


Book ID
107615315
Publisher
Springer Japan
Year
2010
Tongue
English
Weight
383 KB
Volume
24
Category
Article
ISSN
0914-7187

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The cocaine analogue P-CIT-FE (N-(2-fluoroethyl)-2~-carbomethoxy-3~-(4-iodopheny1)nortropane) was labeled with ' lC for positron emission tomography (PET) studies of the dopamine transporter. After intravenous administration to a cynomolgus monkey, ["CIP-CIT-FE accumulated in the striatum with a str