## Abstract ## BACKGROUND BRCA1 and BRCA2 alterations are associated with an increased risk of developing breast carcinoma. The authors hypothesized that the progression of breast neoplasia may differ between patients with hereditary disease and patients with nonhereditary disease and that this di
Quantitative Analysis of BRCA1 and BRCA2 mRNA Expression in Sporadic Breast Carcinomas and Its Relationship with Clinicopathological Characteristics
β Scribed by Egawa, Chiyomi ;Miyoshi, Yasuo ;Taguchi, Tetsuya ;Tamaki, Yasuhiro ;Noguchi, Shinzaburo
- Book ID
- 108582028
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 2001
- Tongue
- English
- Weight
- 99 KB
- Volume
- 92
- Category
- Article
- ISSN
- 0910-5050
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Sporadic breast carcinoma is associated with multiple genetic alterations. The clinical relevance of these alterations, however, needs further clarification. In the present study we analyzed 266 spontaneously arising breast carcinomas for allelic losses in the BRCA1 and TP53 regions on chromosome 17
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