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Quantitation of Phosphorothioate Oligonucleotides in Human Blood Plasma Using a Nanoparticle-Based Method for Solid-Phase Extraction

✍ Scribed by Maier, Martin; Fritz, Hans; Gerster, Michael; Schewitz, Jens; Bayer, Ernst


Book ID
120590760
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
114 KB
Volume
70
Category
Article
ISSN
0003-2700

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Based on a novel method for solid-phase extraction using cationic polystyrene nanoparticles, the suitability of the extraction procedure for quantitation of terminally and backbone-modified antisense oligonucleotides was investigated. Extractions were carried out from both human plasma and urine. Qu