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Quantitation of IgM- and IgG-secreting B cells in the peripheral blood of patients with systemic lupus erythematosus

✍ Scribed by Dennis M. Klinman; Akira Shirai; Yoshiaki Ishigatsubo; Jacqueline Conover; Alfred D. Steinberg

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
595 KB
Volume
34
Category
Article
ISSN
0004-3591

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McLean ## Cross-reactivity of IgG anti-DNA-secreting B cells in patients with systemic lupus erythematosus This study is the first to analyze the cross-reactivity of in vivo activated B cells from patients with systemic lupus erythematosus. A chamber ELIspot assay was used to determine whether ly

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## Abstract Systemic lupus erythematosus (SLE) is characterized by increased numbers of circulating B cells activated polyclonally to secrete immunoglobulin. Because T cells secrete, or shed, various factors that are functionally important in regulating immunoglobulin production by B cells, a rever