Quantitation of HTLV-I provirus among seropositive blood donors: Relation with antibody profile using synthetic peptides
✍ Scribed by Masayuki Matsumura; Shigeki Kushida; Yoshihiro Ami; Tetsuya Suga; Kazuhiko Uchida; Tsuneo Kameyama; Akira Terano; Yukiko Inoue; Hiroshi Shiraki; Kazuo Okochi; Hiroyuki Sato; Masanao Miwa
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- French
- Weight
- 353 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
To study the pathophysiological state of HTLV‐1 carriers and the quantitative aspect of the risk of HTLV‐1 infection, we measured the absolute amounts of HTLV‐1 provirus in 39 seropositive blood donors. The amount of provirus varied from less than one to more than 10^4^ molecules per 10^5^ peripheral‐blood mononuclear cells (PBMC). The average amount of HTLV‐1 provirus among seropositive blood donors was estimated as 3.7 × 10^3^ molecules per 10^5^ PBMC. The titer of the antibody against only the synthetic peptide (aa 100 to 130) of the gag p19 region of the HTLV‐1 provirus showed a weak but significant correlation with the amount of the provirus.