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Quantitation of endogenous liver apolipoprotein B mRNA editing

โœ Scribed by J.W. Backus; M.J. Eagleton; S.G. Harris; C.E. Sparks; J.D. Sparks; H.C. Smith

Book ID
115763695
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
922 KB
Volume
170
Category
Article
ISSN
0006-291X

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Apolipoprotein (apo) B mRNA editing is a genetic regulatory mechanism whereby nucleotide 6666 in apo-B-100 mRNA is converted from a C to a U. The end result of this change is the creation of a premature stop codon so that the translation product of the edited (apoB-48) mRNA contains 2152 amino acids