Quantitation of an Acetaldehyde Adduct in Human Leukocyte DNA and the Effect of Smoking Cessation
β Scribed by Chen, Li; Wang, Mingyao; Villalta, Peter W.; Luo, Xianghua; Feuer, Rachel; Jensen, Joni; Hatsukami, Dorothy K.; Hecht, Stephen S.
- Book ID
- 126417172
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 87 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0893-228X
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π SIMILAR VOLUMES
Among biomarkers of tobacco smoke (TS)-induced genotoxic damage, benzo[a]pyrene diolepoxide-DNA adducts (BPDE-DNA) are extensively studied. Adducted DNA becomes antigenic and antibodies anti-BPDE-DNA (BPDE-DNA-Abs) may be found in serum of exposed subjects. Little is known about the persistence of B
The use of antibodies to detect chemical carcinogen-induced DNA damage involves quantitative determination and morphological localization utilizing antisera specific for carcinogen-DNA adducts. In recent years a large number of polyclonal and monoclonal antisera have been produced against individual