Quantitation of amorphicity by microcalorimetry
β Scribed by D. Giron; P. Remy; S. Thomas; E. Vilette
- Publisher
- Springer Netherlands
- Year
- 1997
- Tongue
- English
- Weight
- 361 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0022-5215
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π SIMILAR VOLUMES
The amorphous content of model drugs was evaluated by isotherm microcalorimetry. Two model drugs were employed; lactose as a hydrophilic one and erythromycin as a hydrophobic one. When amorphous lactose was loaded in a sample cell with a water vial, a sharp exothermic peak due to the crystallization
The structural relaxation time is a measure of the molecular mobility involved in enthalpy relaxation, and thus, is a measure of the dynamics of amorphous (glassy) pharmaceutical solids that determines physicochemical properties and reactivity of drugs in amorphous formulations. In this article we d