✦ LIBER ✦

Quantitation of 5-hydroxymethylfurfural (5-HMF) and related substances in dextrose injections containing drugs and bisulfite

✍ Scribed by Cheryl L. Hryncewicz; Michael Koberda; Mary S. Konkowski

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 317 KB
Volume: 14
Category: Article
ISSN: 0731-7085
DOI: 10.1016/0731-7085(95)01622-8

No coin nor oath required. For personal study only.

✦ Synopsis

The spectrophotometric test for 5-hydroxymethylfurfural and related substances, which is included in multiple compendial monographs for dextrose-containing injections, was modified to eliminate interference of bisulfite anion. Experimental formulations containing heparin or dopamine hydrochloride were used in this study. The modified assay was shown to be accurate, precise and rugged. With an appropriate standard, the method can be used to measure 5-HMF in solutions with an approximate quantitation limit of 0.06 ppm.

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