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Quantitation of 3-Deoxyglucosone Levels in Human Plasma

โœ Scribed by Sundeep Lal; Francis Kappler; Michael Walker; Trevor J. Orchard; Paul J. Beisswenger; Benjamin S. Szwergold; Truman R. Brown

Book ID
115566528
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
116 KB
Volume
342
Category
Article
ISSN
0003-9861

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3-deoxyglucosone (3-DG) is accumulated not only in uremic serum but also in uremic erythrocytes. 3-DG rapidly reacts with protein amino groups to form advanced glycation end products (AGEs) such as imidazolone, pyrraline, and N(epsilon)-(carboxymethyl)lysine, among which imidazolone is the AGE that